January is by far the best month, wherein you can get cheapest flights for Denver to Panama City. Meanwhile, is perceived as the expensive month due to the varying factors. That’s why it’s highly advised to make advanced online flight booking to save huge amounts of money.
Disclaimer - All the above-mentioned fares were found within last 48 hrs. The displayed fares are based on historical data and are subject to change. The fares cannot be guaranteed at the time of booking.

Denver
14:50
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
13:46
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
11:47
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
06:33
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
21:38
Denver
Denver International Airport
Sat , 24 Jan 2026

Panama City
05:33
Panama City
Tocumen International Airport
Sun, 25 Jan 2026

Denver
11:29
Denver
Denver International Airport
Sat , 24 Jan 2026

Panama City
13:27
Panama City
Tocumen International Airport
Sun, 25 Jan 2026

Denver
19:23
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
15:52
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
23:59
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
13:27
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
00:30
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
13:55
Panama City
Tocumen International Airport
Fri, 23 Jan 2026

Denver
16:43
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
13:55
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
21:38
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
05:33
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
17:30
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
14:10
Panama City
Tocumen International Airport
Sat, 24 Jan 2026

Denver
21:38
Denver
Denver International Airport
Fri , 23 Jan 2026

Panama City
05:33
Panama City
Tocumen International Airport
Sat, 24 Jan 2026










Flying from Denver to Panama City has never been easier. Whether you’re planning a short business trip, a weekend getaway, or reconnecting with family and friends, Easemytrip brings you the best deals, seamless booking, and flexible options for this popular flight route. Our platform is built to help travellers like you compare flight prices, explore direct and connecting options, and find the perfect departure time — all within a few clicks.
The air route between Denver to Panama City is one of the most frequently travelled, offering reliable services from top airlines and excellent connectivity between Denver International Airport (DEN) and Tocumen International Airport (PTY). You can expect a flight distance of approximately 4242 km, and most direct services cover it in around 16:25.
Let’s take a closer look at everything you need to know before booking your flight from Denver to Panama City.
| Flight Details | Information |
|---|---|
| Route Distance | 4242 km |
| Average Flight Time | 16:25 hrs |
| Departure Airport | Denver International Airport (DEN) |
| Arrival Airport | Tocumen International Airport (PTY) |
| Cabin Classes Available | Economy Class, Premium Economy, Business Class, First Class |
| Direct Flights | YES |
| Common Airlines | Aeromexico, United Airlines, Copa Airlines, American Airlines |
The route is serviced regularly by both full-service and budget airlines, catering to all types of travellers — from those looking for no-frills budget options to those preferring business and first-class comfort. If you're flying for business, early morning weekday flights are a great choice, while leisure travellers often opt for weekend and evening departures.